Also known as: 高木さんめ, 高木さん, 타카기양, 元高木さん, 高木さん(からかい上手の高木さん)
Title protagonist of Karakai Jouzu No Takagi-San. She is a middle school student in Class 1-2 and a blunt girl who likes teasing her classmate, Nishikata. Easily recognized for her brown, Medium Hair and Parted Bangs that reveal her prominent Forehead.
She wears a Serafuku consisting of a Blue Sailor Collar, Red Neckerchief, long sleeved White Shirt, blue Pleated Skirt, blue shorts under the skirt, and black Kneehighs.
In Karakai Jouzu No (Moto) Takagi-San she is married to Nishikata and they have a child, Chii.
She is voiced by Takahashi Rie in Japanese, and Sarah Wiedenheft (Seasons 1-3) and Kayli Mills (Season 2) in English.