A breed of large Dog originating from Germany. They have tall legs, long bodies, floppy ears, and fur coming in various colors from solid brown, black, brindle, grey, or black-and-white spots.
Danny (Jojo) from Jojo No Kimyou Na Bouken is a Harlequin Great Dane. Scooby-Doo, the eponymous character of the Scooby-Doo (Series) series, is designed after the breed as well.